Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

González-Rodríguez, Julio C. and González-Romero, Carlos and Cuevas-Yáñez, Erick and Mejía Vega, Juan J. and Jankowski, Christopher K. and Corona-Becerril, David (2021) Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis. International Journal of Organic Chemistry, 11 (02). pp. 55-71. ISSN 2161-4687

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Official URL: https://doi.org/10.4236/ijoc.2021.112006

Abstract

Reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde was used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.

Item Type:	Article
Subjects:	Impact Archive > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	28 Feb 2023 08:57
Last Modified:	30 Dec 2023 13:13
URI:	http://research.sdpublishers.net/id/eprint/655

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