SURFACTANTS IN PHARMACEUTICAL APPLICATIONS

Surface active agents (surfactants) are among the most versatile chemicals used in various areas and known to play an important role in many processes of interest; in fundamental and applied science, such as cleaners, paints, cosmetics, pharmaceuticals, food, medicine and biochemical research. Over the years, the use of surfactants has increased considerably. Especially, the use of surfactants with different roles in sample-preparation methodologies is a great contribution to minimizing the problems arising from pre-processing or primary production processes such as recovery, purification of raw materials or to enhance quality of finished products such as an emulsifier, an extraction medium, solubilizing agent and excipients in pharmacy. In addition to these properties, surfactant micelles provide an attractive model system for bio-membranes. Knowledge and understanding of surfactant systems have led to the development of successful models to provide useful information for industrial applications. This mini review has been intended to provide information and general references of surfactants used in the field of pharmacy and presented under forth sections: i) surfactants commonly used in pharmacy and pharmaceutical applications ii) micellar binding of drugs and interactions iii) micellar solubilization iv) surfactants in drug delivery.