Recent Study Hepatoprotective Activity of Morus alba (Linn). Leaves Extract against Carbon Tetrachloride Induced Hepatotoxicity in Rats

Aim: To investigate the hepatoprotective activity of Morus alba Linn. leaves extracts against carbon
tetrachloride (CCl4) induced hepatotoxicity.
Materials and Methods: Leaves powder of Morus alba was successively extracted with petroleum
ether extract (PEE), chloroform extract (CHE), alcoholic extract (ALE) and water extract (AQE)
against carbon tetrachloride (CCl4) induced hepatotoxicity and using Standard drug is Liv-52.
Preliminary phytochemical tests were done.
Results: The ALE showed presence of alkaloids, flavonoides, carbohydrates, tannins and steroids,
while carbohydrates, flavonoides, alkaloids were present with AQE. The PEE, CHE, ALE did not
produce any mortality. Carbon tetrachloride produced significant changes in biochemical parameters
(increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate
transaminase (SGOT), alanine phosphatase (ALP) and serum bilirubin.), histological (damage to
hepatocytes). using Standard drug Liv-52. Pretreatment with ALE and AQE extracts significantly
prevented the biochemical and histological changes induced by CCl4 in the liver.
Conclusion: The present study that shows the ALE and AQE extracts possessed hepatoprotective
activity.