Phytochemical and Antiepileptic Activity of the Ethanol Leaf Extracts of Culcasia falcifolia in Pentylenetetrazole Induced Seizure in Mice

Portia, A. Gracelyn and Mwaniki, D. M. and Ng’wena, A. G. M. and Wanjala, P. M. (2019) Phytochemical and Antiepileptic Activity of the Ethanol Leaf Extracts of Culcasia falcifolia in Pentylenetetrazole Induced Seizure in Mice. In: Recent Advances in Biological Research Vol. 4. B P International, pp. 56-64. ISBN 978-93-89246-50-6

Full text not available from this repository.

Abstract

Aim: To investigate the phytochemicals and the anticonvulsant activity of the ethanol leaf extract of
Culcasia falcifolia used in the traditional medical treatment of epilepsy.
Methodology: The phytochemical screening was carried out using standard protocol while the
anticonvulsant activity was studied using Pentylenetetrazole in mice.
Result: The preliminary phytochemical screening carried out on the ethanol extract of Culcasia
falcifolia revealed the presence of alkaloids, flavonoids, saponins, tannins, polyphenols, and
glycosides. In the anticonvulsant activity, there was a significant (*p< 0.05, **p<0.01) increase in the
mean latency of tonic convulsion (243.72 ± 6.90*, 402.56 ± 5.52**) and significant (*p< 0.05, **p<0.01)
decrease in the mean duration of tonic convulsion (192.62 ± 7.72*, 158.99 ± 8.66**) in a dosedependent
manner at the dose of 200 and 400 mg/kg body wt. respectively. The extract at 400 mg/kg
body wt. showed 100% protection against mortality.
Conclusion: The results of this study suggest that the ethanol leaf extract of Culcasia falcifolia
possesses anticonvulsant activity in PTZ induced seizure in mice. Therefore, the findings of the
present study, suggests that ethanol extract of Culcasia falcifolia leaves has anticonvulsant activity
against PTZ-induced seizures in mice by modulating GABA receptor-mediated inhibitory
neurotransmission, reducing the T-type of Ca++ currents, activating GABAA receptors and facilitating
the GABA-mediated opening of Chloride channel. Based on the folkloric claims, we infer that the
decoction of the leaves of Culcasia falcifolia could be integrated into health care system for the
management of epilepsy.

Item Type: Book Section
Subjects: Impact Archive > Biological Science
Depositing User: Managing Editor
Date Deposited: 22 Nov 2023 05:06
Last Modified: 22 Nov 2023 05:06
URI: http://research.sdpublishers.net/id/eprint/3547

Actions (login required)

View Item
View Item