Research on Synthesis and Anti Convulsant Activity of Novel Oxadiazole Substituted Phenothiazine Derivatives

The purpose of this research is directed towards the synthesis and evaluation of novel agents for the treatment of a variety of neurological disorders. In the past, the phenothiazine nucleus has been thoroughly investigated for various biological activities. The oxadiazole substituted phenothiazine has piqued interest as a potential treatment for a variety of neurological disorders. In light of these findings, researchers attempted to synthesise substituted phenothiazine and test them for anticonvulsant activity. Strychnine and 4-aminopyridine mediated models were used to test the anti-convulsant efficacy of synthesised compounds. These compounds can be used for ligand based drug designing purpose by which exact molecular mechanism responsible for showing anti-convulsant effect can be explored in future.