Association of Vitamin D Deficiency with Knee Osteoarthritis (KOA) in Population of Tamil Nadu, India

The objective of this study is to evaluate the serum 25-OH vitamin D status in patients with knee osteoarthritis (KOA) scheduled for joint replacement along with healthy individuals for comparison. This pilot study conducted in and around the Chennai city and rural places of Tamil Nadu population. Study subjects were selected during the medical camps conducted by our teaching hospital in and around the Chennai city and rural places of Tamil Nadu. . This study showed that about 5 patients out of 10 with knee osteoarthritis were vitamin D deficient with serum levels <10 ng/ml. The study also tried to correlate serum levels of vitamin D with related anthropometric predisposing factors such as age, gender, and BMI. A significant association with gender was observed, with female patients having lower serum levels of vitamin D. Identification of high risk subjects and correction of risk factors such as low level serum 25-OH vitamin D in KOA patients will give beneficial effects and even decreases fracture risk in elderly people.