The Effect of Free Radical Scavenger N-Tert-Butyl-α-Phenylnitrone (PBN): A study on A Stroke Model Rat

In the present study, M-SHRSP was dosed with PBN in drinking water to see how it affected spontaneous stroke in rats. In addition to measuring water intake and body weight, changes in HR, DBP, SBP, and locomotor activity were also observed using a telemetric system. To explore the effects of the radical scavenger N-tert-butyl- -phenylnitrone (PBN) on stroke, we used malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) as a stroke model. M-SHRSP received PBN administered by drinking water. In addition to measuring water intake and body weight, the M-SHRSP's circadian cycles of heart rate, blood pressure, and locomotive activity were also observed. Stroke-onset was assessed by changes in neurological symptoms, water intake, and body weight. Circadian rhythms were basically the same between PBN-treated and control rats several days after stroke onset. Blood pressure, heart rate, relative brain weight, water intake, and motor activity were all significantly different between the two groups. Because of this, there was no discernible difference in the age at which strokes began between PBN-treated and control rats, whereas PBN-treated rats had longer average lifespans. PBN could be useful in extending life.