In vivo Antithrombotic Activity of Ethanolic Extract from Ocimum basilicum L.

Kuerban, Abudukadeer and Almulaiky, Yaaser Q. and Sheikh, Ryan A. and Alzahrani, Saeed Ahmed and Al-Talhi, Hasan A. and Nasrullah, Md and Moselhy, Said Salama and Abulnaja, Khalid Omar (2017) In vivo Antithrombotic Activity of Ethanolic Extract from Ocimum basilicum L. Annual Research & Review in Biology, 20 (5). pp. 1-6. ISSN 2347565X

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Abstract

Aims: In this study, the antithrombotic activity of ethanolic extract from Ocimum basilicum L. was investigated on mice. The active component of Ocimum basilicum L. was extracted in 40% ethanol by Soxhlet extractor.

Place and Duration of Study: Department of Pharmacology, Faculty of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, China, between February, 2009 and July, 2009.

Methodology: The crude extract was gavaged to mice in different concentration (100mg/ml, 200 mg/ml, and 400 mg/ml), for 21 days, Salvia Tablets were used as a positive control. On the final day, 50 mg/kg carrageenan was injected intraperitoneally to induce blood coagulation. Fibrin degradation products (FDPs) were assayed.

Results: Results showed that the content of mice FDPs significantly(P<0. 05)increased in the 200 mg/ml dose group and 400mg/ml dose group compared to the control group. This was dose-dependent.

Conclusion: The ethanolic extract of Ocimum basilicum L can activate the fibrinolytic system so as to stimulate Plasminogen enzyme into fibrinolytic enzyme to show antithrombotic activity.

Item Type: Article
Subjects: Impact Archive > Biological Science
Depositing User: Managing Editor
Date Deposited: 27 Oct 2023 03:45
Last Modified: 27 Oct 2023 03:45
URI: http://research.sdpublishers.net/id/eprint/2770

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