Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri

Luo, Qinghua and Deng, Huaiqing and Yin, Mengguang and Chen, Chen and Zhou, Jiang (2019) Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri. Annual Research & Review in Biology, 32 (4). pp. 1-10. ISSN 2347-565X

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Official URL: https://doi.org/10.9734/arrb/2019/v32i430093

Abstract

This study aimed to describe two cathelicidins (cathelicidin-PR1 and cathelicidin-PR2) from the skin of Paa robertingeri (Anura: Ranidae). The deduced mature peptides cathelicidin-PR1 and cathelicidin-PR2 were composed of 29 and 25 residues, respectively. Cathelicidin - PR1 has higher antimicrobial activity it could kill Gram-positive and Gram-negative bacteria and even some fungal species. Cathelicidin-PR1 exhibited more effective than AMP in antimicrobial activity against Pseydomonas maltophilia clinical strain. On the contrary, cathelicidin-PR2 had very weak antimicrobial activity. Furthermore, cathelicidin-PR1 and cathelicidin-PR2 exhibited very low hemolytic activity against human erythrocytes and little hemagglutinating activity. The results suggested that the cathelicidin-PR1 might serve as a template for developing novel antibiotics.

Item Type:	Article
Subjects:	Impact Archive > Biological Science
Depositing User:	Managing Editor
Date Deposited:	15 Sep 2023 04:19
Last Modified:	15 Sep 2023 04:19
URI:	http://research.sdpublishers.net/id/eprint/2756

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