Formulation Development and Optimization of Multiparticulate System by Extrusion Spheronization Method

Bhise, Kiran and Samuel, Aney Joice (2022) Formulation Development and Optimization of Multiparticulate System by Extrusion Spheronization Method. Journal of Pharmaceutical Research International, 34 (52B). pp. 1-9. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2022/v34i52B7216

Abstract

Aim: This study aimed at formulating and optimizing the multiparticulate system of Rifaximin by adopting 32 factorial designs with independent variables X1 and X2 as concentrations of two excipients.

Methodology: The pellets were prepared by the Extrusion Spheronization method and evaluated for percentage yield, flow property, percentage drug content, friability, and in-vitro percentage cumulative drug release.

Results: The optimized batch (OR7) displayed excellent flow properties, 0.15±0.03% friability, and 97.85±0.22% drug content with a cumulative drug release of 93.24±0.95%.

Conclusion: The results confirm the usefulness of factorial design to identify the effect of variables on pellet characteristics. The optimized batch can further be coated with different polymers to obtain targeted drug delivery.

Place of Study: Department of Pharmaceutics, M. C. E. Society’s Allana College of Pharmacy, Pune.

Item Type:	Article
Uncontrolled Keywords:	Extrusion spheronization; In-vitro release; microcrystalline cellulose; sodium starch glycollate
Subjects:	Impact Archive > Medical Science
Depositing User:	Managing Editor
Date Deposited:	13 Sep 2023 06:42
Last Modified:	13 Sep 2023 06:42
URI:	http://research.sdpublishers.net/id/eprint/2732

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