Hoekstra, Stephanie D. and Stringer, Sven and Heine, Vivi M. and Posthuma, Danielle (2017) Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102
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Abstract
Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.
Item Type: | Article |
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Subjects: | Impact Archive > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 07 Jun 2023 04:33 |
Last Modified: | 07 Dec 2023 03:37 |
URI: | http://research.sdpublishers.net/id/eprint/2443 |