Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity

Hoekstra, Stephanie D. and Stringer, Sven and Heine, Vivi M. and Posthuma, Danielle (2017) Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

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Official URL: https://doi.org/10.3389/fncel.2017.00164

Abstract

Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

Item Type:	Article
Subjects:	Impact Archive > Medical Science
Depositing User:	Managing Editor
Date Deposited:	07 Jun 2023 04:33
Last Modified:	07 Dec 2023 03:37
URI:	http://research.sdpublishers.net/id/eprint/2443

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