Phramacotherapeutic Evaluation of Parmentiera cereifera Seem. (Family Bignoniaceae) Cultivated in Egypt on Albino Rats

Aims: The current study evaluates different biological activities viz., anti-inflammatory, anti-hyperglycemic and gastroprotective of methanolic extracts (MEs) of different parts viz., [mixture of leaves & stems (1:3) (MLS13), flowers and stem barks] and different fractions of ME of MLS13 of ParmentieracereiferaSeem. Moreover, this study estimates LD50of ME of MLS13.Place and Duration of Study:The study was carried out for nine months in 2012 in the Department of Pharmacology, Faculty of Medicine and Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy,Minia University, Minia, Egypt.Methodology:The different MEs of various parts such as MLS13, flowers and stem barks and thedifferent fractions of ME of MLS13 of P. cereiferawere used in the present study. The different pharmacological activities such as anti-inflammatory, anti-hyperglycemic, gastroprotective and LD50were determined using animal models as described in standard methods. Results: In yeast-induced paw edema method,ME of MLS13had the highest anti-inflammatory activity (***P<0.001).While, in carrageenan-induced paw edema method,the highest anti-inflammatory activity (***P<0.001) was exhibited by ME of stem barks. Moreover, both ME of flowers (***P<0.001) and ethyl acetate (EtOAc) fraction (***P<0.01) exhibited significant anti-hyperglycemic activity in alloxan-induced diabetes method. Furthermore, in indomethacin-induced gastric ulcer method, the highest gastroprotective effect (***P<0.001) was demonstrated by the petroleum ether (pet. ether) fraction. Finally, there is no toxicity symptoms of ME of MLS13 of P. cereiferaup to 5 gm/kg.Conclusion: The biological results revealed that P. cereiferamay be used in the development of various pharmaceutical preparations viz., anti-infalammatory, anti-hypergycemic as well as gastroprotective drugs, due to its wide safety margin.