Evaluation of the Efficacy of the Poly- L-Lactic Acid Thread and Platelet Rich Plasma in Treatment of Atrophic Scars

Background: Atrophic scars are the result of insufficient compensation of dermal collagen and decreased production of connective tissue during tissue injury healing. The aim of the study was to evaluate the efficacy of Poly-L- Lactic Acid (PLLA )threads and Platelet Rich Plasma (PRP) in the treatment of atrophic scar.

Methods: This study included 24 patients with atrophic scar for at least one year and did not receive any treatment in the last six months. Cases were divided into 3 equal groups: group (A) received subcision with PLLA threads insertion, group (B) received subcision with PLLA threads insertion and PRP. PRP injected monthly for four sessions and group )C( received subcision with PRP injection monthly for four sessions. general examination, detailed dermatological examination, routine investigations, digital photography: Photographic evaluation was done with the same equipment, lighting and location by 3 dermatologists, and skin biopsies.

Results: There was a significant enhancement in the Global aesthetic improvement scale in both group A and B than group C (p=0.047, 0.017) respectively. In group (A), there was significant negative correlation between duration of scar and the degree of clinical improvement (r -0.961/ p value<0.001) while in group (B) and (C), there was insignificant correlation between duration of scar and the degree of clinical improvement.

Conclusions: PLLA threads alone and combined with PRP injection could be deemed as a safe and useful in the management of atrophic scars.