Neutrophil to Lymphocyte Ratio and Some Cytokines in Pateints with Schizophrenia after Antipsychotic Therapy in Southeast, Nigeria

The aim of the current study was to evaluate neutrophil to lymphocyte ratio and the levels of IL-6, TNF- \(\alpha\) in patients with schizophrenia after six weeks of antipsychotic treatment with Risperidone and Clozapine. Total study sample of 50 subjects of schizophrenia patients and 50 apparently healthy subjects aged 25-60 years were recruited in this study. The cytokines 6 were measured by Enzyme Linked Immunosorbent Assay. The results showed increase in WBC (P=0.001), absolute neutrophil (P=0.000), NLR (P=0.025), IL-6 (P=0.000) and no significant difference in TNF- \(\alpha\) (P=0.059) and no significant difference in absolute lymphocyte of schizophrenia patients before treatment compared to after treatment In conclusion, there were significantly higher values in IL-6, WBC and Neutrophil levels of schizophrenic drug naïve subjects when compared with schizophrenic treated subjects. Tumour Necrosis Factor - alpha serum levels among schizophrenic drug naïve subjects and schizophrenic drug treated subjects showed similar mean values.