Effects of Anti-inflammatory Medication on Indoleamine 2,3 Dioxygenase Activity

Dawood, Shazia and Bano, Samina and Sundus, Sadia and Aijaz, Asma and Samreen, Talat and Usmani, Mohsin Ali (2022) Effects of Anti-inflammatory Medication on Indoleamine 2,3 Dioxygenase Activity. Journal of Pharmaceutical Research International, 34 (35B). pp. 1-5. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2022/v34i35B36166

Abstract

Objective: To study the effects of anti-inflammatory medication on Indoleamine 2,3 dioxygenase activity.

Research Design: This was an investigational study.

Methodology: Eighteen fully grown albino rats separated into control and two treated sets, both treated sets were given indomethacin (50mg/1000g) orally. For acute treatment first treated set was sacrificed after 3.5 hrs & for chronic treatment second set was sacrificed after 3 days. However, control set animals were given an equivalent amount of vehicle.

Results: Outcomes shows that serum Indoleamine 2,3 dioxygenase (IDO) enzyme activity was suppressed after acute treatment while serum IDO activity were increased after chronic treatment however no significant effect was seen on brain IDO.

Conclusion: It is concluded that indomethacin has not shown any significant effect on brain IDO. But inhibits serum IDO activity.

Item Type:	Article
Subjects:	Impact Archive > Medical Science
Depositing User:	Managing Editor
Date Deposited:	06 Mar 2023 05:35
Last Modified:	26 Jun 2024 06:49
URI:	http://research.sdpublishers.net/id/eprint/1567

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