Frequency of Celiac Disease in Type 1 Diabetic Children Presenting at Tertiary Care People Medical College Hospital Nawabshah Pakistan

Objective: The goal of this research has been to find out how common celiac disease is in type 1 children with type 1 diabetes who visit multispecialty hospitals.

Methodology: This was a cross-sectional research. This study was directed at Pediatric Medicine Department, Mother and Child Healthcare (M&CH) ⁄ People Medical College (PMC) Hospital Nawabshah Shaheed Benazeerabad. The length of research was from 07/09/2020 to 06/03/2021, (6 months) next to the authorization of synopsis. Current research included 124 children of together sex aged between 1 to 12 years diagnosed of Type-I diabetes mellitus who were assessed for concomitant presence of celiac disease which was labeled on duodenal biopsy revealing crypt hyperplasia and villous atrophy. Frequency of celiac disease was noted and compared across various subgroups of diabetic children based on age, gender, duration of diabetes, BMI and glycemic control. Each kid's parents signed written consent form.

Results: The average ages of the children were 8.6±2.6 years. The majority of the children (n=68, 54.8 %) were aged 10 and over, preceded by kids aged 6-9 years (36.3 %), and children aged less than 5 years (08.9%). There were 56 (45.2%) boys and 68 (54.8%) girls with boys to girls ratio of 1.1.2. The average lengths of diabetes were 03.2±1.4 year. 51 (41.1%) children had poor glycemic control (HbA1c ≥8.0%). Celiac disease were established in 14 (11.3%) youngsters having Type-I diabetes. Statistically no substantial variance in the frequency of celiac disease across various subgroups of Type-I diabetic children based on age (p =0.966), sex (p =0.854), length of diabetes (p-value=0.985), BMI (p =0.835) & status of glycemic control (p =0.889).

Conclusion: A significant number of children with Type I diabetes had celiac disease in the current study, indicating that regular screening of diabetic children is necessary for prompt detection and management of celiac disease in upcoming clinical settings.