Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study

Katagiri, Hiroki and El Tawil, Yacine and Lang, Niklaus P. and Imber, Jean-Claude and Sculean, Anton and Fujioka-Kobayashi, Masako and Saulacic, Nikola (2021) Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study. Biomedicines, 9 (2). p. 143. ISSN 2227-9059

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Abstract

The aim of this study was to evaluate the influence of additional hydroxyapatite (HA) in collagen-based matrices (CM) and membrane placement on bone formation in calvarial defects. Critical size defects in the calvaria of 16 New Zealand White Rabbits were randomly treated with CM or mineralized collagen-based matrices (mCM). Half of the sites were covered with a collagen membrane. Animals were euthanized after 12 weeks of healing. The samples were studied by micro-CT and histology. Newly formed lamellar bone was observed in all samples at the periphery of the defect. In the central areas, however, new bone composed of both woven and lamellar bone was embedded in the soft tissue. Samples treated with mCM showed more residual biomaterial and induced more small bony islands in the central areas of the defects than samples with CM. Nevertheless, a complete defect closure was not observed in any of the samples at 12 weeks. Membrane placement resulted in a decrease in bone density and height. Significant differences between the groups were revealed only between CM groups with and without membrane coverage for bone height in the central area of the defect. Neither mineralization of CM nor membrane placement improved the osteogenic capacity in this particular defect. Nevertheless, mineralisation influenced bone density without a membrane placement and bone volume underneath a membrane. CM may be used as a scaffold in bone regeneration procedures, without the need of a membrane coverage. Further preclinical studies are warrant to optimise the potential of mCM.

Item Type: Article
Subjects: Impact Archive > Biological Science
Depositing User: Managing Editor
Date Deposited: 31 Jan 2023 05:16
Last Modified: 19 Jun 2024 11:36
URI: http://research.sdpublishers.net/id/eprint/1203

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