Mocarski, Edward S. and Mandal, Pratyusha (2021) TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. PLOS Biology, 19 (8). e3001371. ISSN 1545-7885
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Official URL: https://doi.org/10.1371/journal.pbio.3001371
Abstract
In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.
| Item Type: | Article |
|---|---|
| Subjects: | Impact Archive > Biological Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 03 Mar 2023 05:52 |
| Last Modified: | 22 Jun 2024 07:57 |
| URI: | http://research.sdpublishers.net/id/eprint/1113 |
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