No Evidence for Association of -2518 A/G Promoter Polymorphism of MCP-1 with Risk of Esophageal Cancer in Punjab, North-West India

Sambyal, Vasudha and Guleria, Kamlesh and Manjari, Mridu and Sudan, Meena and Uppal, Manjit and Singh, Neeti (2017) No Evidence for Association of -2518 A/G Promoter Polymorphism of MCP-1 with Risk of Esophageal Cancer in Punjab, North-West India. Journal of Cancer and Tumor International, 6 (2). pp. 1-10. ISSN 24547360

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Official URL: https://doi.org/10.9734/JCTI/2017/36431

Abstract

Aim: To investigate the role of MCP-1 -2518 A/G polymorphism in the susceptibility to esophageal cancer in patients from Punjab, North-West India.

Methods: In this case-control study, 159 sporadic esophageal cancer patients and 159 age and gender matched controls were included. MCP-1 -2518 A/G promoter polymorphism was analyzed using PCR-RFLP method.

Results: The frequencies of GG, GA, and AA genotypes were 43.40%, 47.80% and 8.80% in patients, and 47.17%, 44.65%, 8.18% among the controls respectively. There were no significant differences in genotype and allele frequencies between the patients and controls.

Conclusion: In this study, we found no association between MCP-1 -2518 A/G polymorphism and the esophageal cancer risk in North-West Indians.

Item Type:	Article
Subjects:	Impact Archive > Medical Science
Depositing User:	Managing Editor
Date Deposited:	17 Feb 2023 06:38
Last Modified:	17 Jan 2024 03:50
URI:	http://research.sdpublishers.net/id/eprint/1070

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