Fertility sparing treatment in young patients with early endometrial adenocarcinoma

Jafari Shobeiri, Mehri and Mostafa Gharabaghi, Parvin and Esmaeili, Heidarali and Ouladsahebmadarek, Elaheh and Mehrzad-Sadagiani, Mahzad (2013) Fertility sparing treatment in young patients with early endometrial adenocarcinoma. Pakistan Journal of Medical Sciences, 29 (2). ISSN 1681-715X

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Abstract

Objective: The aim of this study was to evaluate fertility-sparing therapy in young patients with endometrial carcinoma.

Methodology: This prospective study was carried out on 8 patients with clinical and radio-graphic stage IA, well differentiated endometrioid adenocarcinoma of the endometrium in Alzahra hospital, Tabriz, Iran. Treatment comprised high-dose megestrol acetate. Dilatation and curettage was repeated every three months.

Results: The mean age of the patients was 30 (SD,3.21) years (range 24-35). Of the 8 patients, 7 (87.5%) achieved complete response. The mean time to response was 6.5 months (range 3-9). Of the complete responders, 3 of 7(42.8%) had recurrence; one patient underwent immediate hysterectomy, and 2 were successfully treated with second-line therapy and both subsequently conceived. Conception occurred in 3 of 7 patients (42.8%), in two more than once, However successful pregnancy occurred only in two patients. One patient developed Concomitant ovarian adenocarcinoma.

Conclusions: High dose progestin therapy can be an effective fertility-sparing treatment in young patients with well differentiated stage IA endometrial endometrioid cancer confined to endometrium. However, close follow up is required because of risks of conservative treatment.

Item Type: Article
Subjects: Impact Archive > Medical Science
Depositing User: Managing Editor
Date Deposited: 16 May 2023 05:06
Last Modified: 18 Jan 2024 11:27
URI: http://research.sdpublishers.net/id/eprint/2293

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