Journal of Pharmaceutical Research International

Abstract

This study was carried out to evaluate catalase and manganese in type 2 diabetes mellitus patients. A total of 40 subjects Were included in this study. This comprised of equal number of male and female subjects respectively. Enzyme linked immunosorbent assay (ELISA) method was used for this study. The result showed that there is a significant increase (P < 0.05) in the fasting blood sugar level of male diabetics (11.3±3.1) when compared with male non diabetics (4.0±0.4), and female diabetics (9.4±0.8) when compared with female non-diabetics (3.8±0.3). There is no significant increase (P<0.05) in the mean catalase value of male diabetics (77.3±137.7) when compared with male (256.3±207.6) and female non diabetics (225.1±233.9) But there is significant increase in female diabetics (27.8±14.7) when compared with controls (77.3±137.7) and female non diabetics (225.1±233.9).There is also significant decrease (P<0.05) in the mean Manganese value of male diabetics (0.5±0.6) when compared with male non diabetics (0.9±0.3) and female diabetic(0.2±0.1) when compared with female non-diabetics (0.3±0.1).The result shows that serum catalase level and manganese is decreased in diabetic patients. It is therefore suggested that type 2 diabetes patient should consume meals and supplement rich in catalase and manganese.